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What does science tell us about CBD?

What does the research say?


What Does Science Tell Us About CBD?

  1. Introduction
  2. Early Research
  3. Endocannabinoid System
  4. Current Research
  5. Conclusion
  6. References


What does science tell us about CBD? Even today its uses are still undergoing research, scrutiny and testing to better understand its benefits. Let examine this from several perspectives. 1) What is the early research on CBD? 2) How does CBD work with the body? 3) What is the current research saying? 4) What are the research takeaways?

Early Research

CBD, or cannabidiol, is a compound found in the cannabis plant that is currently the subject of extensive research to understand its potential benefits and effects on the human body. Early research on CBD has shown promising results in various areas. For instance, studies suggest that CBD may help reduce anxiety, aid in insomnia, manage chronic pain, and lower cravings for substances like tobacco and heroin1. However, it's important to note that more high-quality evidence from human studies is needed to determine effective doses and fully understand its benefits1.

Endocannabinoid System

CBD works with the body by interacting with the endocannabinoid system, which is involved in regulating a range of functions such as sleep, mood, appetite, and pain. Research has shown that CBD may influence this system and other brain signaling systems, leading to potential benefits for conditions like anxiety, insomnia, and chronic pain1,5.

Experts are not entirely certain about how CBD interacts with the endocannabinoid system (ECS). However, it is known that CBD does not bind to the CB1 or CB2 receptors the way THC does. Instead, it is believed that CBD may work by preventing endocannabinoids from being broken down, allowing them to have a more significant effect on the body. Some researchers also suggest that CBD may bind to a receptor that has not yet been discovered. The effects of this interaction depend on where the receptor is located and which endocannabinoid it binds to. For example, endocannabinoids might target CB1 receptors in a spinal nerve to relieve pain, or they might bind to a CB2 receptor in immune cells to signal that the body is experiencing a common sign of autoimmune disorders4.

In addition, CBD has been found to inhibit endocannabinoid signaling in a dose-dependent manner, and it is a non-competitive antagonist of the CB1 receptor with a low affinity for the CB1 receptor's primary ligand site. It is also thought to modulate overall ECS tone by binding to the CB1 receptor's allosteric site and altering the potency of other primary ligands, such as endocannabinoids and THC3.

While the exact mechanism of how CBD interacts with the ECS is still under debate, research suggests that it may have potential benefits for pain, nausea, and other symptoms associated with various conditions4.

Current Research

Current research on CBD continues to explore its potential benefits and effectiveness. A retrospective observational study suggested that CBD-rich treatments have a beneficial impact on pain, anxiety, and depression symptoms for some patients3. However, further investigation is needed to fully understand the extent of its effects and to substantiate the wide range of health claims associated with CBD3.


While early research on CBD shows promise for managing various conditions, including anxiety, insomnia, and chronic pain, more high-quality human studies are needed to establish its effectiveness and safety. Current research indicates potential benefits, but further investigation is required to fully understand the range of its effects and to substantiate the many health claims associated with CBD.


Johnny PachecoJohn "Johnny P" Pacheco

The founder of Inspiro, LLC – "Johnny P" — is committed to offering the finest quality products at reasonable prices. In fact, we test every batch of CBD for purity. Our focus is on CBD Isolate and related products that are THC-free, as well as education and learning about CBD and its uses and impact on our lives.

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Product Uses

There are many ways our CBD products can be used. Regardless of your application, you can rest assured that Inspiro CBD is tested for purity and is THC-Free.

  • Bath Bombs
  • Creams
  • Capsules
  • Edibles
  • Gels
  • Gummies
  • Lotion
  • Oral Sprays
  • Salves
  • Shampoo
  • Massage Oils


~ Merle Parsons5-Star CBD Review

Excellent product. Everthing as advertised. Very affordable. Just ordered another!

~ Dennis Schneiderwentl5-Star CBD Review

Use this daily in my morning coffee and have been for several years now. I recommend for anyone to try. It works. My older puppy takes 30-40mg daily and it is amazing. Best I've found and I live in Colorado where there is CBD in every place possible for sale. Buy it!

~ NerdTitan5 Star Review

Bought this product to make gummies and it's great!

~ Amazon Customer5-Star CBD Review

I use this to make my pain relief cream. With a few essential oils and Shea butter . . . instant, long lasting relief.

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